GW501516 (also known as GW-501,516, GW1516, GSK-516, Cardarine, and on the black market as Endurobol) is a PPAR receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s.

it helped enhance endurance, stamina and metabolism it has gotten very popular amongst bodybuilders and athletes. It’s now known as the strongest endurance enhancer and best supplement for muscle gain out there.

How cardarine Works?

It works in two ways

1) by binding to and activating PPAR-delta in your cells and

2) by stimulating the genes responsible for energy use.

Cardarine blocks the formation of fatty acid chains which stops body from storing fat. This forces your body to use existing fat stores for energy. It also increases the oxygen usage of slow twitch fibers in your muscles; helping to improve performance and recovery.

Cardarine increases the levels of HDL (good cholesterol) that transfers cholesterol from the periphery to liver for metabolism and decreases the levels of LDL (bad cholesterol) that work antagonistic to HDL. Cardarine also improves liver function and allows body to get rid of any excess fat. Overall, these result in decrease in triglyceride, cholesterol, glucose levels in the body.

Endurable dose

Cardarine (GW-501516) has a half-life of roughly 12-24 hours. This means you will have to dose it twice a day. Most people dose it once in the morning and once in the evening, this will keep levels in the body stable. The length of the cycle should be no more than 6-8 weeks. Once again, you will probably see some users take it for more than 8 weeks but that is quite a risk.

During clinical studies, researchers used dosages of 2.5 mg to 10 mg per day for 12 weeks at a time. Bodybuilders and fitness enthusiasts will use anywhere from 10 to 20mg of Cardarine per day. A typical SARMs stack that includes GW501516 will last anywhere from 6 to 8 weeks. But cardarine shows it’s eye catching effect in 3 to 4 weeks practically.

It is always suggested to play it safe and keep the dosage low and the cycle length relatively short.

You can either take a single dose or you can divide it into multiple doses, since it has a half-life of about 24 hours. Many users start with a 10mg dose and bump it up to 20 or 30mg after a few weeks or leading up to a sporting event

Cardarine with another supplement

The combination of Ostarine and Cardarine is very powerful. Ostarine is great at preserving muscle mass and might even help build some extra size. Whereas Cardarine has the ability to improve physical performance and boost fat loss. This stack is one you don’t see very often.


  • Fat burning
  • Muscle growth
  • Stamina growth
  • Protects Heart and Blood Vessels.
  • Shows noticeable results on the first dose.
  • Can be used while cutting OR bulking
  • No need for a PCT (post cycle therapy).
  • Nontoxic.


Cardarine is popular among bodybuilders despite not being legal or approved for use in humans. Organizations such as the World Anti-Doping Agency have issued warnings about its blatant toxicity.